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. 1984 Sep;4(9):1929-34.
doi: 10.1128/mcb.4.9.1929-1934.1984.

Posttranscriptional modulation of gene expression in cultured rat hepatocytes

D M Jefferson, D F Clayton, J E Darnell Jr, L M Reid

Posttranscriptional modulation of gene expression in cultured rat hepatocytes

D M Jefferson et al. Mol Cell Biol. 1984 Sep.

Abstract

The maintenance of high levels of two liver-specific mRNAs in cultured hepatocytes was achieved in a serum-free hormonally defined cell culture medium. However, this maintenance of liver-specific mRNA levels did not correlate with the level of transcription of the genes but was apparently due to increased stabilization of the tissue-specific mRNAs. The mRNA stabilization did not occur in serum-supplemented medium. In both defined and serum-supplemented medium, actin and tubulin mRNAs were also greatly increased, in both cases predominantly if not entirely due to increased mRNA stability.

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