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. 1984 Sep:14 Suppl B:13-21.
doi: 10.1093/jac/14.suppl_b.13.

Development of resistance to beta-lactam antibiotics with special reference to third-generation cephalosporins

E Collatz, L Gutmann, R Williamson, J F Acar

Development of resistance to beta-lactam antibiotics with special reference to third-generation cephalosporins

E Collatz et al. J Antimicrob Chemother. 1984 Sep.

Abstract

The resistance mechanisms associated with changes in the outer membrane permeability and in beta-lactamase and penicillin-binding-protein production are reviewed. The prevalence of membrane permeability- and chromosome-mediated beta-lactamase-related resistance in Gram-negative bacteria, and of PBP-related resistance in Gram-positive bacteria, with respect to third-generation cephalosporins, is outlined. The frequency of overall resistance to these compounds in two Parisian hospitals during 1983 did not exceed 2% in Enterobacteriaceae but was close to 15% in Pseudomonas sp.

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