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Case Reports
. 1978 Feb;18(2):146-7.
doi: 10.1097/00005373-197802000-00016.

Acute leukopenia associated with silver sulfadiazine therapy

Case Reports

Acute leukopenia associated with silver sulfadiazine therapy

P Valente et al. J Trauma. 1978 Feb.

Abstract

A patient with a 30% scald burn was treated with topical silver sulfadiazine (Silvadene). On two occasions, within 48 hours of treatment, the patient developed acute leukopenia. Bone marrow aspiration revealed cell maturation arrest. The possible mechanisms of this leukopenia are discussed. It is recommended that daily leukocyte counts be done in burn patients being treated with silver sulfadiazine.

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