Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Dec;26(6):937-8.
doi: 10.1128/AAC.26.6.937.

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice

E B Fraser-Smith, D A Eppstein, Y V Marsh, T R Matthews

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice

E B Fraser-Smith et al. Antimicrob Agents Chemother. 1984 Dec.

Abstract

The acyclic nucleoside DHPG [9-(1,3-dihydroxy-2-propoxymethyl)guanine] and recombinant human alpha-interferon of clones A/D potentiate each other's antiviral activity against a systemic infection with herpes simplex virus type 2. The effective dose at which 50% of the mice survived was lowered approximately 10-fold for DHPG when it was given in combination with a marginally effective dose of alpha-interferon and greater than 10-fold for alpha-interferon when it was given in combination with a nontherapeutic dose of DHPG.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Infect Dis. 1978 Feb;137(2):122-30 - PubMed
    1. Antimicrob Agents Chemother. 1981 Apr;19(4):672-4 - PubMed
    1. Infect Immun. 1981 Jun;32(3):995-9 - PubMed
    1. J Biol Chem. 1982 Oct 10;257(19):11497-502 - PubMed
    1. Antimicrob Agents Chemother. 1984 May;25(5):563-5 - PubMed