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. 1983 Jan;153(1):558-61.
doi: 10.1128/jb.153.1.558-561.1983.

Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine

M Simon, J S Hong

Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine

M Simon et al. J Bacteriol. 1983 Jan.

Abstract

Mutations were found which enable Escherichia coli K-12 to form homocysteine in the absence of cystathionase. The formation of homocysteine in the mutant strains required cystathionine gamma-synthetase, the metB gene product, but bypassed the normal intermediate cystathionine. It is concluded that cystathionine gamma-synthetase catalyzes the formation of homocysteine directly from O-succinylhomoserine and an as-yet-unidentified sulfur donor. The mutation apparently causes the formation of this sulfur donor and has been named metQ. The expression of the metQ gene is under catabolite repression.

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References

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