Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1983 Jan;153(1):566-70.
doi: 10.1128/jb.153.1.566-570.1983.

CFA/I-ST plasmids: comparison of enterotoxigenic Escherichia coli (ETEC) of serogroups O25, O63, O78, and O128 and mobilization from an R factor-containing epidemic ETEC isolate

B E Murray, D J Evans Jr, M E Penãranda, D G Evans
Comparative Study

CFA/I-ST plasmids: comparison of enterotoxigenic Escherichia coli (ETEC) of serogroups O25, O63, O78, and O128 and mobilization from an R factor-containing epidemic ETEC isolate

B E Murray et al. J Bacteriol. 1983 Jan.

Abstract

Colonization factor antigen I (CFA/I) plays an important role in the pathogenesis of diarrhea due to enterotoxigenic Escherichia coli. In this study, we examined 11 CFA/I+ enterotoxigenic E. coli from serogroups O25, O63, O78, and O128 and found that with all strains, spontaneous loss of CFA/I was associated with the loss of heat-stable toxin (ST) and with the loss of a single plasmid ranging in size from 54 to 60 megadaltons; when heat-labile toxin was lost, this was associated with the loss of another plasmid. The R factor of one strain, TX432 (O78:H12:CFA/I+; ST+), was found to mobilize the CFA/I-ST plasmid into E. coli K-12 at a frequency of 20%. These studies provide further evidence that CFA/I production is plasmid mediated in enterotoxigenic E. coli belonging to serogroups O25, O63, O78, and O128.

PubMed Disclaimer

References

    1. J Bacteriol. 1979 Sep;139(3):850-8 - PubMed
    1. Infect Immun. 1979 Feb;23(2):325-9 - PubMed
    1. J Infect Dis. 1980 Jun;141(6):702-11 - PubMed
    1. J Clin Microbiol. 1980 Aug;12(2):235-42 - PubMed
    1. Annu Rev Microbiol. 1980;34:465-96 - PubMed

Publication types

LinkOut - more resources