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. 1983 Jan;32(1):1-5.
doi: 10.4269/ajtmh.1983.32.1.

Quinine loading dose in cerebral malaria

N J White, S Looareesuwan, D A Warrell, M J Warrell, P Chanthavanich, D Bunnag, T Harinasuta

Quinine loading dose in cerebral malaria

N J White et al. Am J Trop Med Hyg. 1983 Jan.

Abstract

In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.

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