doi: 10.1111/j.1365-2133.1983.tb00058.x.
Immunohistochemical localization of laminin, type IV and type V collagen in basal cell carcinoma
- PMID: 6337617
- DOI: 10.1111/j.1365-2133.1983.tb00058.x
Item in Clipboard
Immunohistochemical localization of laminin, type IV and type V collagen in basal cell carcinoma
Br J Dermatol.
1983 Feb.
Abstract
Laminin, type IV and type V collagen were localized in twenty-five basal cell carcinomas (BCCs) by immunofluorescence. All basal cell carcinomas were separated from the connective tissue by a continuous basement membrane (BM) which always contained the three antigenic determinants. Nodular and cystic BCCs, but not pagetoid BCCs, contain linear and globular deposits of these BM components. The linear deposits probably represent BM debris that remains undigested and the globular deposits correspond to residual cytoplasmic fragments occurring during apoptosis. These results suggest that BM components are synthesized by epithelial cells and are secreted to polymerize at the dermo-epidermal junction.
Similar articles
-
Discontinuity of the basement membrane in fibrosing basocellular carcinomas and basosquamous carcinomas of the skin: an immunohistochemical study with human laminin and type IV collagen antibodies.J Invest Dermatol. 1984 Mar;82(3):248-51. doi: 10.1111/1523-1747.ep12260190. J Invest Dermatol. 1984. PMID: 6366075
-
Behavior of the basement membrane during carcinoma cell invasion in chemically induced carcinomas of the skin.Acta Anat (Basel). 1996;155(1):1-13. doi: 10.1159/000147784. Acta Anat (Basel). 1996. PMID: 8811110
-
Skin calcium-binding protein immunoreactivity in basal cell carcinoma.Br J Dermatol. 1983 Oct;109(4):383-91. doi: 10.1111/j.1365-2133.1983.tb04612.x. Br J Dermatol. 1983. PMID: 6354242
-
Hepatocellular carcinoma: expression of basement membrane glycoproteins. An immunohistochemical approach.J Pathol. 1987 Aug;152(4):325-32. doi: 10.1002/path.1711520411. J Pathol. 1987. PMID: 2822885
-
Basement membrane laminin and type IV collagen in various benign and malignant adnexal tumors of the skin: an immunohistochemical study.J Invest Dermatol. 1984 Oct;83(4):276-80. doi: 10.1111/1523-1747.ep12340360. J Invest Dermatol. 1984. PMID: 6090537
Cited by
-
Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas.J Clin Invest. 1989 Dec;84(6):1916-23. doi: 10.1172/JCI114379. J Clin Invest. 1989. PMID: 2556449 Free PMC article.
-
Lectin-binding abnormalities in the stromal and epithelial components of basal cell carcinoma.Br J Cancer. 1985 Jul;52(1):117-22. doi: 10.1038/bjc.1985.158. Br J Cancer. 1985. PMID: 2410002 Free PMC article. No abstract available.
-
Enhanced expression of nidogen 1 around the nest of basal cell carcinoma compared with that around squamous cell carcinoma.Med Mol Morphol. 2019 Jun;52(2):99-105. doi: 10.1007/s00795-018-0207-x. Epub 2018 Oct 1. Med Mol Morphol. 2019. PMID: 30276677
-
The immunocytochemical demonstration of basement membrane deposition in transitional cell carcinoma of bladder.Virchows Arch A Pathol Anat Histopathol. 1989;414(5):447-52. doi: 10.1007/BF00718629. Virchows Arch A Pathol Anat Histopathol. 1989. PMID: 2499101
-
Development of the basal lamina in xenografted human carcinomas: an ultrastructural and immunohistochemical study.Cell Tissue Res. 1991 Dec;266(3):563-78. doi: 10.1007/BF00318598. Cell Tissue Res. 1991. PMID: 1811885
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
