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. 1983 Jan;32(1):257-65.
doi: 10.1016/0092-8674(83)90516-0.

Rat myoblast fusion requires metalloendoprotease activity

C B Couch, W J Strittmatter

Rat myoblast fusion requires metalloendoprotease activity

C B Couch et al. Cell. 1983 Jan.

Abstract

The calcium-dependent fusion of cultured rat myoblasts to multinucleate myotubes appears to require the activity of a neutral metalloendoprotease at the time of fusion. Metalloendoprotease inhibitors and synthetic dipeptide substrates prevent myoblast fusion when added to fusion-competent myoblasts with the addition of calcium. Metalloendoprotease activity has been identified and partially characterized in myoblast membranes with a fluorogenic protease substrate, and is inhibited by the same compounds that prevent fusion.

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