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. 1983 Mar;48(3):497-501.

Pretreatment of mice with anti-IgD serum does not result in suppression of immune responsiveness induced by TNP-AECM-Ficoll or lipopolysaccharide

D W Dresser, R M Parkhouse, A M Popham

Pretreatment of mice with anti-IgD serum does not result in suppression of immune responsiveness induced by TNP-AECM-Ficoll or lipopolysaccharide

D W Dresser et al. Immunology. 1983 Mar.

Abstract

Unlike the suppression of a primary response to a thymus-dependent antigen, pretreatment of mice with anti-IgD serum has no effect on the response to a thymus-independent (TI) antigen. It has also been shown that anti-IgD serum injected parenterally into mice 2 days previously, has no suppressive effect on non-specific responsiveness to an intraperitoneal injection of LPS. There is a similar lack of effect on the non-specific element of responsiveness to a TI antigen. These results provide in vivo confirmation of the results of previous in vitro experimentation.

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