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Clinical Trial
. 1983 Jan;51(1):99-102.

Ascorbate (1g/day) does not help the phagocyte killing defect of X-linked chronic granulomatous disease

N Foroozanfar, C F Lucas, D V Joss, K Hugh-Jones, J R Hobbs
Clinical Trial

Ascorbate (1g/day) does not help the phagocyte killing defect of X-linked chronic granulomatous disease

N Foroozanfar et al. Clin Exp Immunol. 1983 Jan.

Abstract

Three patients with X-linked chronic granulomatous disease of childhood (CGD) were treated with a single daily dose of 1 g of vitamin C over a period of 8 months. Prior to this clinical trial, isolated leucocytes from patients and normals were incubated with different concentrations of ascorbate and intracellular killing activity was investigated. Contrary to previous reports, there was no improvement of polymorphonuclear (PMN) intracellular killing activity after oral administration of ascorbate, nor could in vitro ascorbate correct defective, or enhance, killing activity of normal PMNs.

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