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. 1983 Jun 1;51(11):2035-40.
doi: 10.1002/1097-0142(19830601)51:11<2035::aid-cncr2820511113>3.0.co;2-8.

Some effects of combination chemotherapy with cis-platinum on renal function in patients with nonseminomatous testicular carcinoma

S Meijer, D T Sleijfer, N H Mulder, W J Sluiter, J Marrink, H S Koops, T M Brouwers, J Oldhoff, G K van der Hem, E Mandema

Some effects of combination chemotherapy with cis-platinum on renal function in patients with nonseminomatous testicular carcinoma

S Meijer et al. Cancer. .

Abstract

Renal function in 24 patients with disseminated nonseminomatous testicular carcinoma treated with combination chemotherapy including cis-platinum was examined prospectively. Renal function was monitored by several determinations of glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and serum creatinine, and beta-2-microglobulin. A reduction in GFR and ERPF was found at the end of the induction chemotherapy and at six weeks thereafter. Median GFR and ERPF decreased both 23% (P less than 0.01). Serum creatinine and beta-2-microglobulin concentrations however did not rise. It is suggested that under the influence of chemotherapy with platinum the production of creatinine and beta-2-microglobulin is decreased rendering their serum levels unsuitable as parameters of renal function.

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