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. 1983 Jan 1;209(1):251-5.
doi: 10.1042/bj2090251.

Certain mouse strains are deficient in a kidney brush-border metallo-endopeptidase activity

J S Bond, J D Shannon, R J Beynon

Certain mouse strains are deficient in a kidney brush-border metallo-endopeptidase activity

J S Bond et al. Biochem J. .

Abstract

Preparations of microvilli from kidneys of BALB/c mice contain an alkaline metallo-endopeptidase, meprin (metallo-endopeptidase from renal tissue). Certain genealogically related inbred mice are markedly deficient in meprin activity. The meprin-deficient strains (CBA/J and C3H/HeJ) exhibit normal levels of other brush-border enzymes: alkaline phosphatase, aminopeptidase M and another proteinase, a phosphoramidon-sensitive neutral endopeptidase. Meprin deficiency cannot be attributed to a shift in pH optimum and is unlikely to be due to the presence of endogenous inhibitors.

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