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. 1978 Mar 23;272(5651):329-33.
doi: 10.1038/272329a0.

Brain histamine receptors as targets for antidepressant drugs

P D Kanof, P Greengard

Brain histamine receptors as targets for antidepressant drugs

P D Kanof et al. Nature. .

Abstract

A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.

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