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. 1983 Apr;23(4):622-5.
doi: 10.1128/AAC.23.4.622.

Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants

A Jaffé, Y A Chabbert, E Derlot

Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants

A Jaffé et al. Antimicrob Agents Chemother. 1983 Apr.

Abstract

beta-Lactam-resistant mutants of Escherichia coli K-12 were selected by using 12 different beta-lactam derivatives. The mutants fell into three categories showing (i) altered permeation through reduction or loss of outer membrane porin proteins (including ompF, ompR, and envZ alleles); (ii) increase in the rate of synthesis of chromosomally mediated beta-lactamase; or (iii) defective synthesis or action of cyclic adenosine 3',5'-phosphate (cya and crp alleles).

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References

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