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. 1983 May;104(1):1-9.
doi: 10.1093/genetics/104.1.1.

Involvement of gene 49 in recombination of bacteriophage T4

J Miyazaki, Y Ryo, T Minagawa

Involvement of gene 49 in recombination of bacteriophage T4

J Miyazaki et al. Genetics. 1983 May.

Abstract

The role of T4 gene 49 in recombination was investigated using its conditional-lethal amber (am) and temperature-sensitive (ts) mutants. When measured in genetic tests, defects in gene 49 produced a recombination-deficient phenotype. However, DNA synthesized in cells infected with a ts mutant (tsC9) at a nonpermissive temperature appeared to be in a recombinogenic state: after restitution of gene function by shifting to a permissive temperature, the recombinant frequency among progeny increased rapidly even when DNA replication was blocked by an inhibitor. Growth of a gene 49-defective mutant was suppressed by an additional mutation in gene uvsX, but recombination between rII markers was not.

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