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. 1983 Jun 15;113(2):605-10.
doi: 10.1016/0006-291x(83)91769-2.

Bone marrow transplantation for Niemann-Pick mice

T Sakiyama, M Tsuda, M Owada, K Joh, S Miyawaki, T Kitagawa

Bone marrow transplantation for Niemann-Pick mice

T Sakiyama et al. Biochem Biophys Res Commun. .

Abstract

The Niemann-Pick mice which received bone marrow transplants showed a decreased accumulation of sphingomyelin and cholesterol quantitatively in their spleen. The sphingomyelin deposit in the bone marrow was also reduced histochemically. However, the neurological manifestations were not improved by the bone marrow graft.

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