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. 1978 Feb;5(2):307-15.
doi: 10.1093/nar/5.2.307.

360 MHz PMR studies on the involvement of the Y-nucleoside in the conformation of 2'-OMeGpApApYpAppsi from torula yeast tRNAphe

P Dea, M Alta, S Patt, M P Schweizer
Free PMC article

360 MHz PMR studies on the involvement of the Y-nucleoside in the conformation of 2'-OMeGpApApYpAppsi from torula yeast tRNAphe

P Dea et al. Nucleic Acids Res. 1978 Feb.
Free PMC article

Abstract

360 MHz measurements of chemical shifts, 3J1'-2', and T1 as a function of temperature for various protons of the hexanucleotide 2'-OMeGpApApYpAppsi from torula yeast tRNAphe have revealed a unique involvement of the Yt base in the structure and conformation of this oligonucleotide. Whereas the adenosine residues in the anticodon triplet are relatively stable to temperature increase, the Yt readily undergoes destacking and a change in ribose conformation. The destacking most likely involves a torsional displacement of the Yt base occasioned by a rotation of the phosphate-ribose backbone. The possible relevance of this unusual behavior to the influence of the Yt residue in tRNA function in protein biosynthesis is discussed.

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References

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