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. 1983 Aug;155(2):937-9.
doi: 10.1128/jb.155.2.937-939.1983.

Chloramphenicol acetyltransferase may confer resistance to fusidic acid by sequestering the drug

G N Proctor, J McKell, R H Rownd

Chloramphenicol acetyltransferase may confer resistance to fusidic acid by sequestering the drug

G N Proctor et al. J Bacteriol. 1983 Aug.

Abstract

Enterobacterial chloramphenicol acetyltransferase bound fusidic acid with high affinity, but did not acetylate the drug at an experimentally detectable rate. The enzyme may therefore confer resistance to fusidic acid by sequestering the drug and thereby preventing the drug from binding to translational elongation factor G.

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References

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