doi: 10.1111/1523-1747.ep12543766.
Ultrastructural documentation of HLA-DR antigen reactivity in normal human acrosyringial epithelium
- PMID: 6348181
- DOI: 10.1111/1523-1747.ep12543766
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Ultrastructural documentation of HLA-DR antigen reactivity in normal human acrosyringial epithelium
J Invest Dermatol.
1983 Aug.
Free article
Abstract
We have observed that monoclonal antibodies directed against human Ia-like antigens react with a subset of epidermal keratinocytes as well as Langerhans cells in normal human skin. Membrane reactivity for HLA-DR antigen in flattened ductal keratinocytes and in adjacent cuticular cells forming the acrosyringial lumen was observed using immunoelectron microscopy. It should be recognized that Ia-positive acrosyringial keratinocytes represent a potential source of contamination in methods designed to study and isolate Langerhans cells using antibodies directed against HLA-DR antigens. Teleologic considerations of HLA-DR antigen expression in the acrosyringium are discussed.
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