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. 1983;190(2):344-8.
doi: 10.1007/BF00330662.

RNA polymerase rifampicin resistance mutations in Escherichia coli: sequence changes and dominance

Y A Ovchinnikov, G S Monastyrskaya, S O Guriev, N F Kalinina, E D Sverdlov, A I Gragerov, I A Bass, I F Kiver, E P Moiseyeva, V N Igumnov, S Z Mindlin, V G Nikiforov, R B Khesin

RNA polymerase rifampicin resistance mutations in Escherichia coli: sequence changes and dominance

Y A Ovchinnikov et al. Mol Gen Genet. 1983.

Abstract

Five recombinant plasmids, pBK2646, pBK611, pRC3, pRC4 and pRC5, carrying rpoB rifampicin-resistant RNA-polymerase genes were obtained. The sequence analysis of these plasmids revealed certain structural changes in the rpoB gene which specify corresponding alterations in the beta-subunit of RNA polymerase. Some functional properties of the corresponding mutant strains and their RNA polymerases have been investigated.

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