Effect of a timed interval between inhalation of beta-agonist and corticosteroid aerosols on the control of chronic asthma
- PMID: 6348995
- PMCID: PMC459562
- DOI: 10.1136/thx.38.5.378
Effect of a timed interval between inhalation of beta-agonist and corticosteroid aerosols on the control of chronic asthma
Abstract
A randomised double-blind crossover study was undertaken in 25 patients with variable airflow obstruction to assess the benefit of separating the inhalation of beta-agonist aerosols and corticosteroid aerosols by a timed interval of more than five minutes. Twenty-two patients (11 men and 11 women) completed 12 weeks of study; they inhaled 200 micrograms salbutamol followed either immediately or after a timed interval by 100 micrograms beclomethasone dipropionate two to four times daily. Morning and evening peak expiratory flow rates, symptom scores, additional beta-agonist inhaler usage, and subjective responses on a visual-analogue scale were recorded throughout. Results from the two last four-week periods, with and without the interval between drugs, were analysed. No differences were found. It is concluded that the theoretical benefit of delaying corticosteroid inhalation until optimum bronchodilatation has been achieved with a beta-agonist is not demonstrable in outpatient practice.
Similar articles
-
How important is the sequence of administration of inhaled beclomethasone dipropionate and salbutamol in asthma.Br J Dis Chest. 1981 Jul;75(3):273-6. doi: 10.1016/0007-0971(81)90005-x. Br J Dis Chest. 1981. PMID: 7028071 Clinical Trial.
-
The superiority of combination beclomethasone and salbutamol over standard dosing of salbutamol in the treatment of chronic asthma.Ann Allergy. 1989 Jan;62(1):63-6. Ann Allergy. 1989. PMID: 2912326 Clinical Trial.
-
Increased inhaled bronchodilator vs increased inhaled corticosteroid in the control of moderate asthma.Chest. 1992 Dec;102(6):1709-15. doi: 10.1378/chest.102.6.1709. Chest. 1992. PMID: 1446477 Clinical Trial.
-
Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma.N Engl J Med. 2007 May 17;356(20):2040-52. doi: 10.1056/NEJMoa063861. N Engl J Med. 2007. PMID: 17507703 Clinical Trial.
-
Inhaled high-dose beclomethasone in chronic asthma.N Z Med J. 1987 May 27;100(824):306-8. N Z Med J. 1987. PMID: 3330185 Review.
Cited by
-
Therapeutic aerosols 1--physical and practical considerations.Thorax. 1983 Dec;38(12):881-6. doi: 10.1136/thx.38.12.881. Thorax. 1983. PMID: 6364439 Free PMC article. Review. No abstract available.
-
Beclomethasone dipropionate. A reappraisal of its pharmacodynamic properties and therapeutic efficacy after a decade of use in asthma and rhinitis.Drugs. 1984 Aug;28(2):99-126. doi: 10.2165/00003495-198428020-00002. Drugs. 1984. PMID: 6381025 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical