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. 1983 Sep;305(5931):189-93.
doi: 10.1038/305189a0.

Construction of artificial chromosomes in yeast

A W Murray, J W Szostak

Construction of artificial chromosomes in yeast

A W Murray et al. Nature. 1983 Sep.

Abstract

Fifty-five-kilobase long artificial chromosomes containing cloned genes, replicators, centromeres and telomeres have been constructed in yeast. These molecules have many of the properties of natural yeast chromosomes. Centromere function is impaired on short (less than 20 kilobases) artificial chromosomes.

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