Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Sep;80(17):5421-4.
doi: 10.1073/pnas.80.17.5421.

Control of malaria virulence by alpha 1-acid glycoprotein (orosomucoid), an acute-phase (inflammatory) reactant

M J Friedman

Control of malaria virulence by alpha 1-acid glycoprotein (orosomucoid), an acute-phase (inflammatory) reactant

M J Friedman. Proc Natl Acad Sci U S A. 1983 Sep.

Abstract

During malaria and other infections, the plasma concentration of alpha 1-acid glycoprotein (AGP) increases 3- to 4-fold, but the function of this glycoprotein has been unknown. This study demonstrates, by in vitro culture of the malaria parasite Plasmodium falciparum, that the AGP concentration achieved during malaria is sufficient to inhibit parasite multiplication by 80%. It was found that the inhibitory activity of AGP depends on and is a function of its sialic acid complement (12-16 mol/mol) and its higher-order structure. AGP acts by blocking parasite-erythrocyte interaction during the invasion process. These findings indicate a function for AGP with definite in vivo significance. Moreover, they reveal an important protective response to malaria and perhaps other infectious diseases.

PubMed Disclaimer

References

    1. Science. 1976 Aug 20;193(4254):673-5 - PubMed
    1. Arch Intern Med. 1976 Jul;136(7):778-81 - PubMed
    1. J Exp Med. 1977 Jul 1;146(1):277-81 - PubMed
    1. Immunology. 1977 Jun;32(6):997-1005 - PubMed
    1. Am J Trop Med Hyg. 1978 Nov;27(6):1274-6 - PubMed

Publication types

MeSH terms