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Comparative Study
. 1983 Sep;48(3):329-34.
doi: 10.1038/bjc.1983.196.

Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation

M A Cornbleet, T J McElwain, P J Kumar, J Filshie, P Selby, R L Carter, D W Hedley, M L Clark, J L Millar
Free PMC article
Comparative Study

Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation

M A Cornbleet et al. Br J Cancer. 1983 Sep.
Free PMC article

Abstract

Twenty-eight patients with advanced life-threatening metastatic malignant melanoma were treated with high dose (140-260 mgm-2) intravenous melphalan and autologous bone marrow. Cyclophosphamide "priming" 300 mgm-2 i.v. was given to 19 patients one week previously and this resulted in clinical but not histological evidence of amelioration of gastrointestinal toxicity. In 11 patients (43%) there was evidence of tumour response to treatment and in 2 patients complete remissions were observed. However in most patients, responses were short-lived and no patient lived longer than 17 months from start of treatment or 24 months from first recorded evidence of distant metastatic disease.

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