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. 1983 Summer;7(3):299-301.
doi: 10.1111/j.1530-0277.1983.tb05464.x.

Impaired ethanol metabolism with advancing age

H K Hahn, R E Burch

Impaired ethanol metabolism with advancing age

H K Hahn et al. Alcohol Clin Exp Res. 1983 Summer.

Abstract

Ethanol metabolism as a function of age was assessed in male Sprague-Dawley rats. The ethanol metabolic rates decreased linearly with advancing age. It was also observed that a linear decrease in hepatic alcohol dehydrogenase activity occurred as a function of age. The decreased enzyme activity could be the biochemical mechanism underlying changes in ethanol metabolism. Impaired ethanol metabolism may produce increased pharmacologic effects in older subjects due to increased blood ethanol levels.

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