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. 1983 Sep;36(9):1228-35.
doi: 10.7164/antibiotics.36.1228.

Inhibition of nucleic acid biosynthesis in procaryotic and eucaryotic cells by cyanocycline A

T Hayashi, T Okutomi, S Suzuki, H Okazaki
Free article

Inhibition of nucleic acid biosynthesis in procaryotic and eucaryotic cells by cyanocycline A

T Hayashi et al. J Antibiot (Tokyo). 1983 Sep.
Free article

Abstract

Cyanocycline A was cytotoxic against Meth A cells in vitro, and also showed marked activity against the same cell line grown as an experimental ascites tumor. This antibiotic inhibited nucleic acid synthesis in Escherichia coli and Meth A cells. The antimicrobial activity of the antibiotic was reversed by addition of exogenous herring sperm DNA. Cytofluorometric analysis of cyanocycline A-treated Meth A cells showed an unusual pattern of the relative content of DNA and RNA per cell. These results suggested that cyanocycline A binds to DNA, and that it inhibits nucleic acid synthesis.

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