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. 1983 Dec;57(6):1311-3.
doi: 10.1210/jcem-57-6-1311.

Insulin regulates placental lactogen and estradiol secretion by cultured human term trophoblast

Z Hochberg, R Perlman, J M Brandes, A Benderli

Insulin regulates placental lactogen and estradiol secretion by cultured human term trophoblast

Z Hochberg et al. J Clin Endocrinol Metab. 1983 Dec.

Abstract

We have described a human term trophoblast cell culture system which synthesizes hormones de novo from their precursors. In the present report we utilized this monolayer system to show that insulin produced a dose-dependent stimulation of hPL secretion, with a significant effect at 10(-10) M insulin. At 10(-9) M concentration, insulin also inhibited estradiol secretion by the cultured trophoblast. We conclude that insulin regulates secretion of estradiol and placental lactogen by cultured human term trophoblast.

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