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Comparative Study
. 1983 Nov;36(11):1309-11.
doi: 10.1136/jcp.36.11.1309.

A comparison of cellulose acetate immunofixation with polyacrylamide gel electrophoresis for the detection of oligoclonal bands in unconcentrated cerebrospinal fluid

F C Goodland, E J Thompson
Comparative Study

A comparison of cellulose acetate immunofixation with polyacrylamide gel electrophoresis for the detection of oligoclonal bands in unconcentrated cerebrospinal fluid

F C Goodland et al. J Clin Pathol. 1983 Nov.

Abstract

Two methods of electrophoresis for the detection of oligoclonal bands in unconcentrated CSF were compared. A sample of 98 routine CSFs yielded 18 positives by polyacrylamide gel electrophoresis (PAGE) while cellulose acetate electrophoresis with immunofixation (CAIF) gave 13 positives (72% of the PAGE findings). Despite the loss of sensitivity the cellulose acetate electrophoresis was easier to interpret and more suited to a routine hospital laboratory.

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