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. 1976 Aug;57(2):255-61.
doi: 10.1093/jnci/57.2.255.

Interaction analysis of selective and nonselective cell-mediated cytotoxicity

M Takasugi, M R Mickey

Interaction analysis of selective and nonselective cell-mediated cytotoxicity

M Takasugi et al. J Natl Cancer Inst. 1976 Aug.

Abstract

The coexistence of selective and nonselective cytotoxic cells in effector suspensions required a method of separating the two effects before specificities in cell-mediated cytotoxicity could be investigated. A method of analysis was derived which used the average cytotoxicity for each effector and target to estimate selective and nonselective cytotoxic effects. The analysis clearly detected specificity in tests of cell-mediated lympholysis, and application to tests of cell-mediated cytotoxicity on cultured human tumor cells showed that selective reactions were found.

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