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. 1983 Nov;42(2):623-7.
doi: 10.1128/iai.42.2.623-627.1983.

Comparison of major protein antigens and protein profiles of Treponema pallidum and Treponema pertenue

R W Thornburg, J B Baseman

Comparison of major protein antigens and protein profiles of Treponema pallidum and Treponema pertenue

R W Thornburg et al. Infect Immun. 1983 Nov.

Abstract

The protein profiles of Treponema pallidum and Treponema pertenue, the causative agents of syphilis and yaws, respectively, were compared by one- and two-dimensional gel electrophoresis. One-dimensional gels showed essentially no differences in the protein patterns of these treponemes. On two-dimensional gels most radiolabeled protein species were shared; however, variations were noticed in several minor protein species. Antigenic comparison by radioimmunoprecipitation and Western blotting also demonstrated similarities between these spirochetes. However, lactoperoxidase-catalyzed iodination of T. pallidum and T. pertenue suggested differences in their surface proteins.

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