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. 1983 Nov;42(2):838-41.
doi: 10.1128/iai.42.2.838-841.1983.

Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin

F A Klipstein, R F Engert, R A Houghten

Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin

F A Klipstein et al. Infect Immun. 1983 Nov.

Abstract

Klebsiella pneumoniae heat-stable enterotoxin was purified to apparent homogenicity by the same techniques used to purify Escherichia coli heat-stable enterotoxin. The two toxins had the same potency in the suckling mouse assay and showed immunological cross-reactivity in enzyme-linked immunosorbent assay, neutralization of secretory activity by specific hyperimmune antisera, and protection against active challenge in rats immunized with a vaccine containing synthetically produced E. coli heat-stable enterotoxin.

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