Effectiveness of routine periodontal treatment with and without adjunctive metronidazole therapy in a sample of mentally retarded adolescents

Abstract

A sample of mentally retarded adolescents with moderate periodontal disease was given conventional treatment with and without adjunctive metronidazole therapy following consent of guardians. Antibiotics or placebo tables were taken 1 week following prophylaxis in a double blind clinical trial. Six months after the baseline examinations, there were no significant differences between the treatment and control groups in the mean attachment level or the proportions of microorganisms in subgingival pockets.