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. 1983 Nov 11;11(21):7505-15.
doi: 10.1093/nar/11.21.7505.

Selective inactivation of the 3' to 5' exonuclease activity of Escherichia coli DNA polymerase I by heat

P J Lecomte, O P Doubleday
Free PMC article

Selective inactivation of the 3' to 5' exonuclease activity of Escherichia coli DNA polymerase I by heat

P J Lecomte et al. Nucleic Acids Res. .
Free PMC article

Abstract

Heat selectively inactivates the 3' to 5' exonuclease activity of E. coli DNA polymerase I, resulting in reduced dNTP turnover and lower fidelity of replication of homopolymer and natural DNA templates.

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References

    1. Cold Spring Harb Symp Quant Biol. 1966;31:693-7 - PubMed
    1. Nature. 1969 Mar 22;221(5186):1128-32 - PubMed
    1. J Biol Chem. 1970 Oct 25;245(20):5326-34 - PubMed
    1. J Biol Chem. 1972 Jan 10;247(1):241-8 - PubMed
    1. J Biol Chem. 1972 Jun 10;247(11):3393-404 - PubMed

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