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. 1983 Nov;24(5):810-1.
doi: 10.1128/AAC.24.5.810.

Synergism of imipenem and amikacin in combination with other antibiotics against Nocardia asteroides

M E Gombert, T M Aulicino

Synergism of imipenem and amikacin in combination with other antibiotics against Nocardia asteroides

M E Gombert et al. Antimicrob Agents Chemother. 1983 Nov.

Abstract

The in vitro activities of imipenem (formerly imipemide, N-formimidoyl thienamycin, or MK0787) and amikacin in combination with cefotaxime, trimethoprim-sulfamethoxazole, and each other were tested against 26 Nocardia asteroides strains. The agar dilution method was used for all tests. Synergy was present in 80% of tests with imipenem-trimethoprim-sulfamethoxazole, in 92% of tests with imipenem-cefotaxime, and in 83% of tests with amikacin-trimethoprim-sulfamethoxazole. Indifference was found on rare occasions, and no antagonism was seen.

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References

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