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. 1984 Jan;81(1):110-4.
doi: 10.1073/pnas.81.1.110.

Monoclonal antibodies to human urokinase identify the single-chain pro-urokinase precursor

G Salerno, P Verde, M L Nolli, A Corti, H Szöts, T Meo, J Johnson, S Bullock, G Cassani, F Blasi

Monoclonal antibodies to human urokinase identify the single-chain pro-urokinase precursor

G Salerno et al. Proc Natl Acad Sci U S A. 1984 Jan.

Abstract

Monoclonal antibodies have been obtained that recognize either the A or B chain of human urinary urokinase. These antibodies identify human urokinase-producing cells and the product of urokinase mRNA. Anti-urokinase monoclonal antibodies precipitate an approximately equal to 54,000-dalton protein synthesized in vitro in a rabbit reticulocyte cell-free system. This pro-urokinase appears to be the precursor of both A and B chains of human urinary urokinase. Urokinase mRNA in human kidney constitutes only 0.1% or less of total poly(A)+ RNA.

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