Nonspecific vaginitis in an outpatient clinic. Comparison of three dosage regimens of metronidazole

Abstract

Nonspecific vaginitis causes diagnostic as well as therapeutic difficulties in gynecological private practice. In a study in 63 patients with "nonspecific" vaginitis, clinical parameters were related to the bacteriological isolation of G. vaginalis in order to try to find criteria which can help to make a correct diagnosis of "nonspecific vaginitis". These patients were treated with three different regimens of metronidazole, either 2000 mg as a single dose, or two single doses of 2000 mg each taken the first and the third day, or 400 mg 2 times daily for 7 days. Patients with Candida or Trichomonas infections were excluded. Partners were treated at the same time, with the same regimen as the patient. The patients were controlled 14 and 28 days after the beginning of the treatment. The preliminary results showed that all regimens give good clinical effect, but the treatment with 2000 mg given as a single dose the first and the third days seems to lead to fewer failures.