[Progress in diagnosis of gastric function: gastric secretory analysis, intragastric titration, endocrine provocation tests (author's transl)]

Abstract

Diagnostic procedures for the measurement of gastric acid secretion and for the differention between several types of hypergastrinemia have been improved during the last years. An intravenous dose-response curve with increasing doses of pentagastrin resulted in 30% higher MAO compared to subcutaneously administered pentagastrin (6 microgram/kg body weight). Food-stimulated gastric acid secretions can be measured by intragastric titration; this method is used mainly in clinical-physiological studies. The different forms of hypergastrinemia may be differentiated by 3 provocation tests: calciuminfusion, secretintest, glucagontest. In atypical cases of Zollinger-Ellison-Syndrome it may be necessary to perform all 3 tests.