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. 1983 Dec 15;216(3):583-7.
doi: 10.1042/bj2160583.

The role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats

D J Millward, B Odedra, P C Bates

The role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats

D J Millward et al. Biochem J. .

Abstract

Measurements of changes in muscle protein synthesis, insulin and corticosterone in vivo in refed food-deprived rats, some after pretreatment with anti-insulin serum or corticosterone, indicate that the acute increase in protein synthesis (20-40 min) requires (a) insulin, (b) a fall in corticosterone, since corticosterone acts at least in part by blocking insulin action, and (c) at least one other independent anabolic factor.

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