In search of a super solution: controlled trial of glycine-glucose oral rehydration solution in infantile diarrhoea

Abstract

In a double blind trial a glycine fortified oral glucose electrolyte solution was evaluated in a group of infants and small children (n=25) with moderate to severe dehydration due to acute diarrhoea, and was compared with a matched control group (n=26) receiving only glucose based oral rehydration solution. It is seen that the diarrhoea stool output, duration of diarrhoea, and volume of oral rehydration fluid required to achieve and maintain hydration are significantly lower in the group receiving glycine fortified glucose electrolyte solution. The possibility of developing an oral rehydration solution which could also act as an absorption promoting drug is discussed.

PIP: In a double-blind study, a glycine fortified oral glucose electrolyte solution as evalutaed in a group of infants and small children (n=25) with moderate to severe dehydration due to acute diarrhea, and was compared to a matched control group (n=26) receiving only glucose based oral rehydration solution. It was observed that diarrhea stool output, duration of diarrea, and volume of oral rehydration fluid required to achieve and maintain hydration are significantly lower in the group receiving glycine fortified glucose electrolyte solution. The possibility of developing an oral rehydration solution which could also act as a absorption promoting drug is also discussed.