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Case Reports
. 1984 May 15;53(10):2125-8.
doi: 10.1002/1097-0142(19840515)53:10<2125::aid-cncr2820531022>3.0.co;2-u.

Osteogenic sarcoma producing human chorionic gonadotrophin. Case report with immunohistochemical studies

J K Kalra, R Mir, L B Kahn, Z Wessely, A B Shah
Case Reports

Osteogenic sarcoma producing human chorionic gonadotrophin. Case report with immunohistochemical studies

J K Kalra et al. Cancer. .

Abstract

An osteogenic sarcoma occurring in a 22-year-old woman was found to be associated with production of a large amount of beta human chorionic gonadotrophin (B-hCG). Pregnancy was excluded on the basis of a normal ultrasonogram and a proliferative type endometrium obtained by curettage. A homogenate of the tumor was strongly positive for B-hCG while immunohistochemical staining of the tumor cells was strongly positive for B-hCG and negative for pregnancy associated glycoprotein. These results indicate ectopic production of hCG by the osteosarcoma.

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