[Dependence of Escherichia coli K-12 viability and mutability on the balance of DNA and protein syntheses. VI. Molecular mechanisms underlying the phenomena of imbalance death and metabolic mutagenesis]

Abstract

In this report the results of further studies of the molecular mechanisms of the disbalance death and metabolic (disbalance) mutagenesis are presented. As reported previously, the relationship of viability and mutability of Escherichia coli cells from the extent disturbance of DNA-protein synthesis balance is determined by the processes of stabilization and repair of metabolic disbalance gaps in DNA strands. It is established that polB, recB, SSB gene products are involved in the processes of stabilization and repair of metabolic disbalance gaps.