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. 1978 Jan;8(1-2):57-64.
doi: 10.1007/BF01972403.

Naturally occurring low molecular weight inhibitors of neutral proteinases from PMN-granulocytes and of kallikreins

H Fritz, H Schiessler, R Gieger, K Ohlsson, K Hochstrasser

Naturally occurring low molecular weight inhibitors of neutral proteinases from PMN-granulocytes and of kallikreins

H Fritz et al. Agents Actions. 1978 Jan.

Abstract

Human mucous secretions contain low molecular weight (Mr approximately 11,000) acid-stable inhibitors directed against elastase and cathepsin G from PMN-granulocytes. Important biochemical properties of these inhibitors are presented and their possible biological function is discussed. An inhibitor of glandular and plasma kallikreins preventing kinin-liberation from kininogen but not ester hydrolysis was obtained from rat kidney tubules. A molecular weight of about 4700 was estimated for this kallikrein-specific inhibitor (trypsin-induced kinin-liberation is not prevented).

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