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. 1984 Mar;25(3):387-9.
doi: 10.1128/AAC.25.3.387.

In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B

R L Hopfer, K Mills, R Mehta, G Lopez-Berestein, V Fainstein, R L Juliano

In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B

R L Hopfer et al. Antimicrob Agents Chemother. 1984 Mar.

Abstract

The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes caused a significant increase in the minimal fungicidal concentration of amphotericin B in 7 of 19 other yeast strains tested, whereas ergosterol caused an increase in 18 of the 19 strains.

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