Torre's syndrome: report of two cases and review of the literature

Abstract

Two patients with multiple sebaceous adenomas associated with visceral carcinoma (Torre's syndrome) are described, and reported cases in the literature are summarized. Certain aspects of Torre's syndrome are emphasized: that the presence of multiple sebaceous adenomas is a cutaneous marker for visceral carcinomas, that the associated carcinomas are of comparatively low-grade malignancy, and that it is a genetic condition probably related to the Cancer Family syndrome. In addition, three morphologic patterns of the sebaceous adenoma are described: solid, cystic, and "keratoacanthoma-like"; then, the potential pitfalls in the histopathologic interpretation of this tumor are discussed.