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. 1984 May 16;120(3):885-90.
doi: 10.1016/s0006-291x(84)80190-4.

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

G G Glenner, C W Wong

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

G G Glenner et al. Biochem Biophys Res Commun. .

Abstract

A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HC1 in 1 N acetic acid and by high performance liquid chromatography. Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far. This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis.

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