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. 1984 Jun;25(6):785-6.
doi: 10.1128/AAC.25.6.785.

Effect of decreased renal function on the pharmacokinetics of ceftazidime

B H Ackerman, J Ross, R W Tofte, J C Rotschafer

Effect of decreased renal function on the pharmacokinetics of ceftazidime

B H Ackerman et al. Antimicrob Agents Chemother. 1984 Jun.

Abstract

The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in 11 subjects, with creatinine clearances ranging from 113 to 6 ml/min. Concentrations of ceftazidime in serum were determined by microbiological assay. These data were fitted to a two-compartment open model, and pharmacokinetic parameters were calculated. Correlation of ceftazidime clearance with creatinine clearance was excellent (r = 0.99).

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