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. 1978 Feb 15;170(2):257-64.
doi: 10.1042/bj1700257.

The metabolism of shikimate in the rat

D Brewster, R S Jones, D V Parke

The metabolism of shikimate in the rat

D Brewster et al. Biochem J. .

Abstract

In the rat, shikimate was metabolized and excreted as hippurate, hexahydrohippurate, 3,4,5,6-tetrahydrohippurate, t-3,t-4-dihydroxycyclohexane-r-1-carboxylate and c-3,t-4-dihydroxycyclophexane-r-1-carboxylate, conjugates of catechol and CO2. The metabolism was entirely dependent on various initial microbial transformations in the gut, metabolite formation being suppressed in animals pretreated with antibiotics. Shikimate was not metabolized by mammalian tissues, and products of microbial metabolism were excreted either unchanged or after further biotransformation in the animal tissues.

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