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. 1984;6(3):217-22.
doi: 10.1016/0192-0561(84)90019-5.

Combined effects of chemotherapy and host antitumor response in a murine histocompatible lymphoma model

P Marconi, L Scaringi, L Tissi, P Puccetti, A Cassone

Combined effects of chemotherapy and host antitumor response in a murine histocompatible lymphoma model

P Marconi et al. Int J Immunopharmacol. 1984.

Abstract

Combined effects of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and host antitumor immune response were studied in mice inoculated intraperitoneally with histocompatible LSTRA leukemia cells carrying virus-induced transplantation antigens. Marked chemo-immune collaborative activity was found to occur when selected schedules of BCNU administration were employed. Moreover, synergist effects were also detected between chemotherapy and both specific and non-specific immunotherapy.

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