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. 1984 Mar:66:189-94.
doi: 10.1242/jcs.66.1.189.

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue

D A Hume, J F Loutit, S Gordon

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue

D A Hume et al. J Cell Sci. 1984 Mar.

Abstract

The macrophage-specific antigen F4/80 has been localized in adult mouse bone and connective tissue. F4/80 positive cells form the centre of haemopoietic islands, line the periosteal and subendosteal bone surfaces and are a major component of connective tissue and the synovial membrane (presumptive type A cells). F4/80 is absent from fibroblasts, chondrocytes, osteoblasts, osteocytes, osteoclasts and a subpopulation of synovial lining cells (presumptive type B cells).

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